Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling …
Closes 10 Oct 2028 (706 days)
up to USD 2,500,000. National Institutes of Health
Who can apply
- Where
- United States, nationwide
- Industries
- any, or not stated
- Business size
- not stated
- Amount
- up to USD 2,500,000
- Dates
- opens 3 Nov 2026; closes 10 Oct 2028
The funder's text has not been read for criteria yet; open the source for the full rules.
Eligibility, in the funder's words
Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
About the program
This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations. ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED).
Common questions
Am I eligible?
Only National Institutes of Health can say. The rules above are what the notice states; sign in and your business profile is compared with them line by line for a likely, maybe or unlikely verdict.
When does it close?
10 Oct 2028. Save it in your account for reminders 14, 7 and 2 days before.
Where do I apply?
On the funder's page: https://www.grants.gov/search-results-detail/361287
Is this one for you?
Sign in and your state, industry, size and turnover are compared with these rules line by line. Save it for closing reminders.